Why confirmation stalls
Early 70sMCI with elevated plasma p-tau217no PET or CSF yet
Fix the workflow, or fight the access?
60%
Outside constraints
41%
Inside the practice
What matters now
Biologic confirmation of elevated amyloid does not establish treatment readiness. Readiness spans three distinct domains.
Early 70sMCI with elevated plasma p-tau217no PET or CSF yet
Fix the workflow, or fight the access?
60%
Outside constraints
41%
Inside the practice
Late 60sabout to start therapyARIA coordination already informal
The handoff, or the ownership?
41%
The communication pathway
59%
Internal role ownership
Late 60sfour infusions inmild asymptomatic ARIA-E on surveillance MRI
Grade the finding, or read the patient?
54%
Characterizing the finding
46%
Reading the patient
Mid 70samyloid-positive MCIcare partner works full time
Is this the right stage, or the right setup?
27%
Stage and trajectory
73%
Support and infrastructure
A growing DMT panelevery stage at oncethe pathway holds only when tracked
Your personal effort, or patient-to-patient variation?
57%
Dependence on you
43%
Variation across patients
What matters now
Biologic confirmation of elevated amyloid does not establish treatment readiness. Readiness spans three distinct domains.
5 Real World Scenarios
Early 70sMCI with elevated plasma p-tau217no PET or CSF yet
Fix the workflow, or fight the access?
Where does the evidence land?
60%
Outside constraints
41%
Inside the practice
Late 60sabout to start therapyARIA coordination already informal
The handoff, or the ownership?
Where does the evidence land?
41%
The communication pathway
59%
Internal role ownership
Late 60sfour infusions inmild asymptomatic ARIA-E on surveillance MRI
Grade the finding, or read the patient?
Where does the evidence land?
54%
Characterizing the finding
46%
Reading the patient
Mid 70samyloid-positive MCIcare partner works full time
Is this the right stage, or the right setup?
Where does the evidence land?
27%
Stage and trajectory
73%
Support and infrastructure
A growing DMT panelevery stage at oncethe pathway holds only when tracked
Your personal effort, or patient-to-patient variation?
Where does the evidence land?
57%
Dependence on you
43%
Variation across patients